文章简介

出版社:SPINE

作   者:Shunji Matsunaga,Takashi Sakou

编   号:DOI: 10.1097/BRS.0b013e318241ad33

年   份:2012    点击量:273

文章摘要 全文翻译

Study Design

Review article.

研究设计

综述文章。

 

Objective

To review the etiology, natural history, measurement tools, and image diagnosis of ossification of the posterior longitudinal ligament (OPLL) of the cervical spine.

目的

本文旨在对颈椎后纵韧带骨化(OPLL)的病因、自然病程、测量工具以及影像诊断作一综述。

 

Summary of Background Data

OPLL is a well-known disease that causes myelopathy. Genetic factors are very important for development of OPLL. However, the pathogenetic gene and natural history of OPLL have not been clarified.

背景资料概述

后纵韧带骨化是引发脊髓病的一个众所周知的疾病。遗传因素对后纵韧带骨化的发展是非常重要的。然而,后纵韧带骨化的致病基因和自然病程都尚未明确。

 

Methods

The authors reviewed studies about the etiology, natural history, measurement tools, and diagnosis of OPLL, which had been performed by the members of the Investigation Committee on the Ossification of the Spinal Ligaments of the Japanese Ministry of Health, Labour, and Welfare.

方法

作者回顾关于后纵韧带骨化的病因、自然病程、测量工具和诊断的研究,即日本卫生、劳动和福利部的脊柱韧带骨化调查委员会的成员进行的研究。

 

Results

The prevalence of OPLL in the general Japanese population was reported to be 1.9% to 4.3% among people older than 30 years. Genetic factors are important for development of OPLL, and some candidate genes have been reported. Clinical course of OPLL has been clarified by a prospective long-term follow-up study. Some radiographic predictors for development of myelopathy were introduced. Image diagnosis of OPLL is easy by plain radiographs, but magnetic resonance imaging and computed tomography are useful to determine cord compression by OPLL.

结果

据报道,后纵韧带骨化在日本30岁以上总人口的发病率为1.9%至4.3%。遗传因素对后纵韧带骨化的发展是重要的,并且一些候选基因已有报道。后纵韧带骨化的临床病程已通过一项前瞻性长期随访研究明确。对脊髓病的发展引入了一些放射学预测。X片很容易诊断后纵韧带骨化,但MRI和CT有助于确定后纵韧带骨化是否导致脊髓受压。

 

Conclusion

OPLL should be managed on the basis of the consideration of its natural history. Elucidation of pathogenetic genes of OPLL will introduce a new approach for management of OPLL.

结论

后纵韧带骨化的治疗应考虑该疾病的自然史。后纵韧带骨化致病基因的明确将为其治疗带来新方法。