探索用于治疗骨质疏松症的药物输送系统

骨科医师之家  2013年8月13日  阅读数:1098  字体:    

Exploring drug delivery systems for treating osteoporosis


探索用于治疗骨质疏松症的药物输送系统



原文链接:http://informahealthcare.com/doi/abs/10.1517/17425247.2013.785518?prevSearch=allfield%253A%2528orthopedics%2Btrauma%2529&searchHistoryKey=

Introduction: Osteoporosis (OP) is a major disease in elderly people; its complications and prevalence are rapidly increasing worldwide. It is associated with high fragility fracture mainly of hip, wrist and spine. With the rising lifespan worldwide, the number of hip fractures throughout globe will rise from 1.66 million in 1990 to 6.26 million by 2050. So there is a major problem in our society related to the bone diseases which needs to be addressed.

简介:骨质疏松症(OP)是一种老年人多发的疾病,其并发症及发病率呈全球性迅速增加。该病伴随高脆性髋部、腕部及脊柱骨折。随着人类寿命逐渐增长,全球髋部骨折的数量将由1990年的1.66亿增加至2050年的6.26亿。因此,我们需要处理骨疾病相关的主要社会问题。

Areas covered: This review gives knowledge about OP, its symptoms and problems associated with the existing therapies. It gives idea about various drug delivery systems for bone targeting. This review also gives a comprehensive compilation of the various in vitro and in vivo studies conducted till date and US FDA approved drugs for the treatment of OP.

涉及领域:本文介绍了骨质疏松症的相关知识及其与现有治疗相关的症状和问题,提出了各种骨靶向药物输送系统的思路,并汇总了日前各种体外内研究以及获美国FDA批准用于治疗骨质疏松症的药物。

Expert opinion: Various drug delivery systems reduce the adverse effects of drugs and increase the availability of drugs to the target site mainly bones. Active researches are going on to improve the OP treatment, whose high prevalence and considerable functional and socioeconomic impact will raise formidable challenges in the near future. We should work on different targets rather than conventional therapies which will improve the overall treatment strategies.

专家观点:各种药物输送系统可减少药物不良反应,并增加药品供应至目标位点(主要是骨头)。改善骨质疏松症治疗的大量研究涌现,在不久的将来,其高患病率以及很多功能和社会经济影响将会对治疗提出严峻的挑战。我们应将研究重点放在不同靶点而不是只研究常规疗法,这将提高骨质疏松症的整体治疗策略。


责任编辑:王影影